With the evolution in translational medicine and ‘omics’ profiling, precision medicine is finally becoming a reality; and the field of pharmacogenomics (PGx) is at the forefront of this revolution. As we examine the intricacies of tailoring drug treatments to individual genetic profiles, three pivotal entities stand out in leading this movement: the Clinical Pharmacogenetics Implementation Consortium (CPIC), the Dutch Pharmacogenetics Working Group (DPWG), and the Pharmacogenomics Knowledge Base (PharmGKB). Together, these organizations are not only helping to resolve the complexities of pharmacogenomics but also reshaping clinical guidelines to optimize patient outcomes.
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In the ever-changing landscape of drug development, the coupling of pharmacogenomics and pharmacokinetics is becoming a powerful tool in the advancement of personalized medicine. As researchers look deeper into individual genetic variations and their impact on drug response, the promise of tailoring treatments to an individual’s unique genetic makeup is at last becoming a reality. This blog explores the synergy between pharmacogenomics and pharmacokinetics and sheds light on how these two distinct profiles are together reshaping the process of drug development.
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Psychiatric disorders affect millions of people worldwide, often causing significant distress and impacting their daily lives. The current mental health crisis, with one in five adults suffering with some form of mental condition requiring medication, has steadily developed over the last 20 years. Covid exacerbated the challenges, but even over a year after the pandemic, rates of mental health conditions have not returned to pre-pandemic levels.
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