Although giving birth is often described as one of the most beautiful experiences a woman can have, for many mothers, the period following childbirth can be marked by overwhelming emotions, fatigue, and, in some cases, postpartum depression (PPD). Postpartum depression is a serious condition that affects around one in seven women in the US after giving birth, and is characterized by feelings of sadness, anxiety, and exhaustion. While the exact causes of PPD are multifaceted and not fully understood, emerging research suggests that genetics plays a significant role in predisposing some women to this condition. But genetics may also hold the key to optimizing the use of medications to address this debilitating condition, and as new treatment options are approved by the FDA, there finally seems to be progress in this somewhat neglected field of medicine.